Pharmacokinetic and triglyceride­lowering pharmacodynamic effects of icosapent ethyl (eicosapentaenoic acid ethyl ester) across clinical studies

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman R, Bays HE, Ballantyne CM, Stirtan WG, Soni PN. Pharmacokinetic and triglyceride-lowering pharmacodynamic effects of icosapent ethyl (eicosapentaenoic acid ethyl ester) across clinical studies [abstract]. Circulation. 2013;128:A19343.

AMR101, a pure­EPA omega­3 fatty acid, lowers triglycerides in patients with very high triglycerides without raising LDL­C: the MARINE study

Submitted by amarin on Fri, 12/08/2017 - 06:39

Bays HE, Ballantyne CM, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, Soni PN. AMR101, a pure-EPA omega-3 fatty acid, lowers triglycerides in patients with very high triglycerides without raising LDL-C: the MARINE study [abstract]. J Clin Lipidol. 2011;5:205.

The effect of two doses of AMR101 on fasting serum triglycerides and other lipid parameters in statin­treated patients with persistent high triglycerides (200 and <500 mg/dL): the ANCHOR study

Submitted by amarin on Fri, 12/08/2017 - 06:39

Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, Soni PN. The effect of two doses of AMR101 on fasting serum triglycerides and other lipid parameters in statin-treated patients with persistent high triglycerides (200 and <500 mg/dL): the ANCHOR study [abstract]. J Clin Lipidol. 2012;6:279-280.

AMR101, a pure ethyl eicosapentaenoic acid omega­3 fatty acid: effects on inflammation­associated end points from the MARINE and ANCHOR study

Submitted by amarin on Fri, 12/08/2017 - 06:39

Bays HE, Ballantyne CM, Braeckman RA, Stirtan WG, Soni PN. AMR101, a pure ethyl eicosapentaenoic acid omega-3 fatty acid: effects on inflammation-associated end points from the MARINE and ANCHOR study [abstract]. J Clin Lipidol. 2012;6:279.

Phase 1 study of the effect of icosapent ethyl on warfarin pharmacokinetics and anticoagulation pharmacodynamics in healthy subjects

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman RA, Stirtan WG, Soni PN. Phase 1 study of the effect of icosapent ethyl on warfarin pharmacokinetics and anticoagulation pharmacodynamics in healthy subjects [abstract]. J Clin Lipidol. 2013;7:270.

Phase 1 study of the effect of icosapent ethyl on atorvastatin pharmacokinetics in healthy subjects

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman RA, Stirtan WG, Soni PN. Phase 1 study of the effect of icosapent ethyl on atorvastatin pharmacokinetics in healthy subjects [abstract]. J Clin Lipidol. 2013;7:269-270.

Icosapent ethyl (eicosapentaenoic acid ethyl ester): effects on apolipoprotein C­III in patients from the MARINE and ANCHOR studies

Submitted by amarin on Fri, 12/08/2017 - 06:39

Ballantyne CM, Bays HE, Braeckman RA, Stirtan WG, Doyle RT Jr, Juliano R, Soni PN. Icosapent ethyl (eicosapentaenoic acid ethyl ester): effects on apolipoprotein C-III in patients from the MARINE and ANCHOR studies [abstract]. J Clin Lipidol. 2014;8:313-314.

Effects of icosapent ethyl on lipoprotein particle concentration and the fatty acid desaturation index in statin­treated patients with persistent high triglycerides (the ANCHOR study)

Submitted by amarin on Fri, 12/08/2017 - 06:39

Ballantyne CM, Braeckman RA, Bays HE, Kastelein JJ, Otvos J, Stirtan WG, Soni PN. Effects of icosapent ethyl on lipoprotein particle concentration and the fatty acid desaturation index in statin-treated patients with persistent high triglycerides (the ANCHOR study) [abstract]. J Clin Lipidol. 2013;7:270-271.

Pharmacokinetics of eicosapentaenoic acid in plasma and red blood cells after multiple oral dosing with AMR101 (ethyl­eicosapentaenoic acid) in healthy subjects

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman RA, Stirtan WG, Soni PN. Pharmacokinetics of eicosapentaenoic acid in plasma and red blood cells after multiple oral dosing with AMR101 (ethyl-eicosapentaenoic acid) in healthy subjects [abstract]. Presented at: Congress of the International Society for the Study of Fatty Acids and Lipids, Vancouver, Canada, May 26-30, 2012.